报告题目：Mechanobiology of Post Traumatic Knee Osteoarthritis
报 告 人：Professor
University of Melbourne, Australia
Post traumatic knee osteoarthritis (OA) is often associated with extreme loading on the articular surface in our knee joints. An OA joint causes pain affecting patient’s mobility and quality of life. Research in preventing the joints from such degeneration includes tissue engineering, stem cells therapy, reparative surgery, and if unsuccessful, a total joint replacement will be required. A fundamental knowledge needed to improve these efforts lies in understanding how forces are applied to the human, transferred to the tissue and transduced into biological responses. In this aspect, we have developed multi-scale models and experiments to obtain quantitative biomechanical information such as muscles forces, ligament forces, stresses on cartilage and bone in the knee joint related to injury. Human subjects’ jump landing maneuvers common in many sports, such as basketball and skiing that could lead to knee injury, were conducted in a motion analysis laboratory. The kinematics, kinetics, energetics and muscles forces during landing from different heights were quantified. Using data from human subjects’ experiment, non-injurious loadings were scaled into loads that could cause injury using a high-speed mechanical test system on cadavers’ knee specimens. The injury threshold for cartilage and bone damage could then be established. Finally, the human subjects’ and cadavers’ knee joints studies provided data to apply physiological loadings to osteochondral explants, enabling the study of realistic bone microstructure damages and degenerative changes in cartilage and chondrocytes. In addition to these experiments, multi scale lower limb musculoskeletal models and finite element models of cartilage / bone microstructures and chondrocytes were developed. These experimental and computation models will help improve our understanding of cartilage/ bone/ cell injury due to impact loading.
Peter Lee obtained his BEng in Mechanical Engineering (1st Class Hons. 1991) and PhD (1996) in Bioengineering from the University of Strathclyde, UK, and continued his post-doc in the same university from 1996–1998. He was a Research Fellow with the Biomaterials Group at the Institute of Materials Research and Engineering, Singapore from 1998–2001. In 2001, he joined the Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, as the Head of the Bioengineering Laboratory. DSO is the largest research institute in Singapore with 1500 researchers. Lee accumulated significant experience in managing multi-million dollar defence research projects and infrastructure. He pioneered the Bioengineering Laboratory and the Biotechnology Programme in DSO and achieved noteworthy recognitions and awards for his research and management skills. In his career, he had undergone formal management training by the Ministry of Defence Singapore and the IMD Business School Switzerland. He joined the University of Melbourne, Australia, as a Senior Lecturer in 2008, and was promoted to an Associate Professor in 2011 and a Professor in 2015. Since then he has held several leadership positions including Deputy Head and Acting Head of Department of Mechanical Engineering, and currently as the Deputy Head (Research and Engagement) of Department of Biomedical Engineering, and the Melbourne School of Engineering Research Program Leader for Medical and Pharmaceutical Technologies. He also leads the Cell and Tissue Biomechanics Laboratory in Engineering, where his research aims to better understand the behaviour of biological cells and tissues under mechanical forces. He has authored more than 140 publications in journals, conference proceedings and books. He is a regular reviewer for journals and grant bodies and currently the Associate Editor for Journal of Orthopaedic Surgery and Research, and Frontiers in Pharmacology (Translational Pharmacology).